No Evidence of Data Manipulation in Science Publication on Simufilam
JPAD communicated the following statement to the Company on
“We have completed our review of your article “PTI-125 Reduces Biomarkers of Alzheimer’s Disease in Patients” (JPAD 2020;7(4):256-264). We do not find convincing evidence of manipulation of data or intent to mislead, and therefore take no action regarding the published paper.”
“From the onset, I have said that allegations of research misconduct are false, and for good reason – I see no supporting evidence for the allegations,” said
May 2022, Neurobiology of Aging investigated and found no evidence of data manipulation in a paper on simufilam published in that journal in 2017. The journal’s Editor-in-Chief stated: “A reader has made the editors aware of concerns regarding the above-referenced report published at Neurobiology of Aging [i.e., “PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis.” Neurobiol. Aging, 55:99-114]. These issues were conveyed to the authors, who provided a detailed response, including images of relevant uncropped western blots and photomicrographs, as the editor requested. The material was evaluated by an independent expert with relevant methodological expertise, the manuscript was scanned by AI-based figure proofing software (i.e., Proofig), and all available input was considered by the handling editor and Editor-in-Chief. Overall, the editors did not find compelling evidence of data manipulation intended to misrepresent the results.” The journal’s full notice is available on-line:
December 2021, Cassava Sciencesannounced that Neuroscience investigated and found no evidence of data manipulation in a paper published in that journal in 2005. The Editor-in-Chief stated: “After careful examination of these original material, Neuroscience found no evidence of manipulation of the western blot data or other figures of this publication.” The journal’s full editorial note is available on-line:
November 2021, Cassava Sciencesannounced that The Journal of Neuroscienceinvestigated and found no evidence of data manipulation in a paper on simufilam published in that journal in July 2012. The Editor-in-Chief previously authorized Cassava Sciencesto share a statement on this matter, including: “No evidence of data manipulation was found for Western blot data.” The full statement provided to the Company and the journal’s full notice are both available on-line:
A related investigation by academic authorities at
Simufilam is Cassava Sciences’ proprietary, small molecule (oral) drug that restores the normal shape and function of altered filamin A (FLNA) protein in the brain.
For More Information Contact:
Cautionary Note Regarding Forward-Looking Statements: This news release contains forward-looking statements, including statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, relating to: our expectations regarding CUNY’s on-going investigative activities; our viewpoints regarding lack of supporting evidence for allegations of research misconduct; our expectations regarding the role of written pronouncements from science experts; the potential cessation of attacks against the Company; comments made by our employees regarding allegations of data manipulation; the treatment of Alzheimer’s disease; and potential benefits, if any, of our product candidates. These statements may be identified by words such as “may,” “anticipate,” “believe,” “could,” “expect,” “would”, “forecast,” “intend,” “plan,” “possible,” “potential,” and other words and terms of similar meaning. Drug development and commercialization involve a high degree of risk, and only a small number of research and development programs result in commercialization of a product. Our clinical results from earlier-stage clinical trials may not be indicative of full results or results from later-stage or larger scale clinical trials and do not ensure regulatory approval. You should not place undue reliance on these statements or any scientific data we present or publish.
Such statements are based largely on our current expectations and projections about future events. Such statements speak only as of the date of this news release and are subject to a number of risks, uncertainties and assumptions, including, but not limited to, those risks relating to the ability to conduct or complete clinical studies on expected timelines, to demonstrate the specificity, safety, efficacy or potential health benefits of our product candidates, the severity and duration of health care precautions given the COVID-19 pandemic, any unanticipated impacts of the pandemic on our business operations, and including those described in the section entitled “Risk Factors” in our Annual Report on Form 10-K for the year ended
Source: Cassava Sciences, Inc.